Gómez-Boronat M, Isorna E, Conde-Sieira M, Delgado MJ, Soengas JL, de Pedro N.

First evidence on the role of palmitoylethanolamide in energy homeostasis in fish.

Horm Behav. 2019 Oct 21:104609.

DOI: 10.1016/j.yhbeh.2019.104609.

RESUMEN

We have studied the impact of palmitoylethanolamide (PEA) on several components of energy homeostasis in goldfish ("Carassius auratus"). On the energy inflow side, intraperitoneal injection of PEA reduced food intake, probably mediated by an increase in the hepatic leptin and a decrease in the hypothalamic NPY. PEA chronic treatment reduced body weight gain and growth rate. On the side of energy outflow, a marked reduction of locomotor activity was observed after PEA chronic treatment. PEA is also involved in the hepatic metabolism of glucose and lipids, which could be linked with the PEA-induction of the clock gene BMAL1. These results suggest an important role of PEA in the regulation of energy homeostasis in fish.