Gómez-Boronat M, Isorna E, Armirotti A, Delgado MJ, Piomelli D, de Pedro N

Diurnal Profiles of N-Acylethanolamines in Goldfish Brain and Gastrointestinal Tract: Possible Role of Feeding

Front Neurosci. 2019 May 7;13:450

DOI: 10.3389/fnins.2019.00450

RESUMEN

N-acylethanolamines (NAEs) are a family of endogenous lipid signaling molecules that are involved in regulation of energy homeostasis in vertebrates with a putative role on circadian system. The aim of this work was to study the existence of daily fluctuations in components of NAEs system and their possible dependence on food intake in fish. Our data show the presence of all components of NAEs system in goldfish (OEA, PEA, SEA, precursors, synthesis and degradation enzymes, and the receptor PPARα). Moreover, the content of NAEs in the peripheral tissues (but not in the brain) were higher after food intake (1-h postprandial). Overall, our work supports the involvement of NAEs as peripheral satiety signals in fish.